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The Pathogenesis of CLABSIs
There are five chief sources of Central Line-Associated Bloodstream Infections (CLABSIs):
The ErgoPack™ System with ARROWg+ard Blue Plus® or Chlorag+ard® chlorhexidine-based catheters give you a comprehensive approach for helping to prevent each one.
1 O'grady, N.P., Alexander, M., Burns L.A., Dellinger, P., Garland, J., Heard, S.O., Lipsett P.A., Masur, H., Mermel, L.A., Pearson, M.L., Raad, I.I., Randolph, A, Rupp, M.E., Saint, S.. Guidelines for the Prevention of Intravascular Catheter-Related Infections, 2011. The Centers for Disease Control. http://www.cdc.gov/hicpac/pdf/guidelines/bsi-guidelines-2011.pdf. Accessed May 16, 2011.
2 Maki, D., Ringer, M., Alvarado, C.J. Prospective Randomized Trial of Povidone-iodine, Alcohol and Chlorhexidine for Prevention of Infection Associated With Central Venous and Arterial Catheters. Lancet. August 1991; Vol. 338: 339–343.
3 O'Grady, N.P., Alexander, M., Dellinger, E.P., Gerberding, J.L., Heard, S.O., Maki, D.G., Masur, H., McCormick, R.D., Mermel, L.A., Pearson, M.L., Raad, I.I., Randolph, A., Weinstein, R.A. Guidelines for the Prevention of Intravascular Catheter-Related Infections. Centers for Disease Control. August 9, 2002; Vol. 51 (RR10): 7–8.
4 Murphy, D., Whiting, J. Dispelling the Myths: The True Cost of Healthcare-Associated Infections. An APIC Briefing, February 2007.
5 Raad, I.I., Hohn, D.C., Gilbreath, B.J., et al. Prevention of Central Venous Catheter-Related Infections by Using Maximal Sterile Barrier Precautions During Insertion. Infection Control Hospital Epidemiology. 1994; Vol. 15 (4 Pt 1): 231–238.
6 Mermel, L.A., McCormick, R.D., Springman, S.R., Maki, D.G. The Pathogenesis and Epidemiology of Catheter-Related Infection With Pulmonary Artery Swan-Ganz Catheters: A Prospective Study Utilizing Molecular Subtyping. American Journal of Medicine. 1991; Vol. 91 (3B): 197S–205S.
7 Safdar, N., Maki, D.G. The Pathogenesis of Catheter-Related Bloodstream Infection With Noncuffed Short-Term Central Venous Catheters. Intensive Care Medicine. January 2004; Vol. 30(1): 62–67.
8 Maki, D.G., Stolz, S.M., Wheeler, S., Mermel, L.A. Prevention of Central Venous Catheter-Related Bloodstream Infection With an Antiseptic-Impregnated Catheter: A Randomized, Controlled Trial. Annals of Internal Medicine. August 15, 1997; Vol. 127(4): 257–266.
9 Rupp, M.E., Lisco, S.J., Lipsett, P.A., Perl, T.M., Keating, K., Civetta, J.M., Mermel, L.A., Lee, D., Dellinger, P.E., Donahue, M., Giles, D., Pfaller, M.A., Maki, D.G., Sherertz, R. Effect of a Second-Generation Venous Catheter Impregnated With Chlorhexidine and Silver Sulfadiazine on Central Catheter-Related Infections: A Randomized, Controlled Trial. Annals of Internal Medicine, October 18, 2005; Vol. 143(8): 570–581.
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